1. animal which is a hybrid of a horse and a donkey; stubborn person; weaving device; type of slipper that leaves the heel exposed. mulemule (mūl), n. [f., a she-mule, l. mula, fem. of mulus; cf. gr. my`klos, mychlo`s. cf. as. mūl, fr. l. mulus. cf. mulatto.]